Synthesis of 5-Substituted 1H-Tetrazoles from Nitriles by Continuous Flow: Application to the Synthesis of Valsartan

Facile synthesis of 5-substituted-1H-tetrazoles catalyzed by reusable nickel zirconium phosphate nanocatalyst

5-Substituted-1H-tetrazoles were synthesized by the [3 + 2] cycloaddition of sodium azide with various nitriles in the presence of nickel zirconium phosphate (NiZrP) as an effective heterogeneous catalyst in dimethylsulfoxide at 120 °C. This method has the advantages of good to high yields, simple methodology and easy work-up. The catalyst can be recovered by centrifuging and reused with good y...

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Facile synthesis of 5-substituted-1H-tetrazoles catalyzed by reusable nickel zirconium phosphate nanocatalyst

5-Substituted-1H-tetrazoles were synthesized by the [3 + 2] cycloaddition of sodium azide with various nitriles in the presence of nickel zirconium phosphate (NiZrP) as an effective heterogeneous catalyst in dimethylsulfoxide at 120 °C. This method has the advantages of good to high yields, simple methodology and easy work-up. The catalyst can be recovered by centrifuging and reused with good y...

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Montmorillonite KSF as a very efficient heterogeneous catalyst for the synthesis of 5-substituted 1H-tetrazoles

Montmorillonite KSF has been used as an effective and non-toxic heterogeneous catalyst for one-pot synthesis of 5-substituted 1H-tetrazoles via [3+2] cycloaddition of sodium azide with a wide variety of nitriles. The reaction afforded high yields of the desired products in a short reaction time under mild reaction conditions. The catalyst can be recovered by simple filtration and reuse...

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Mesoporous ZnS nanospheres: a high activity heterogeneous catalyst for synthesis of 5-substituted 1H-tetrazoles from nitriles and sodium azide.

Mesoporous ZnS nanospheres is a novel heterogeneous catalyst for synthesis of 5-substituted 1H-tetrazoles from various nitriles and sodium azide with excellent catalytic performance.

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Montmorillonite KSF as a very efficient heterogeneous catalyst for the synthesis of 5-substituted 1H-tetrazoles

Montmorillonite KSF has been used as an effective and non-toxic heterogeneous catalyst for one-pot synthesis of 5-substituted 1H-tetrazoles via [3+2] cycloaddition of sodium azide with a wide variety of nitriles. The reaction afforded high yields of the desired products in a short reaction time under mild reaction conditions. The catalyst can be recovered by simple filtration and reuse...

متن کامل

Synthesis of 5-Substituted 1H-Tetrazoles from Nitriles by Continuous Flow: Application to the Synthesis of Valsartan

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Facile synthesis of 5-substituted-1H-tetrazoles catalyzed by reusable nickel zirconium phosphate nanocatalyst

Facile synthesis of 5-substituted-1H-tetrazoles catalyzed by reusable nickel zirconium phosphate nanocatalyst

Montmorillonite KSF as a very efficient heterogeneous catalyst for the synthesis of 5-substituted 1H-tetrazoles

Mesoporous ZnS nanospheres: a high activity heterogeneous catalyst for synthesis of 5-substituted 1H-tetrazoles from nitriles and sodium azide.

Montmorillonite KSF as a very efficient heterogeneous catalyst for the synthesis of 5-substituted 1H-tetrazoles

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